Detection of tumor progression in optic pathway glioma with and without neurofibromatosis type 1
نویسندگان
چکیده
منابع مشابه
Detection of tumor progression in optic pathway glioma with and without neurofibromatosis type 1.
BACKGROUND We wanted to determine the sensitivity and specificity of serial changes in visual acuity and visual evoked potentials (VEPs) to detect radiological progression of tumor volume in children with optic pathway gliomas. METHODS From a retrospective review of a cohort of 69 patients, 54 patients met inclusion criteria (31 with primary chemotherapy, 4 with primary radiotherapy, and 19 w...
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Neurofibromatosis type 1 is a common neurogenetic disorder characterized by significant clinical variability. As such, numerous studies have focused on identifying clinical, radiographic, or molecular biomarkers that predict the occurrence or progression of specific clinical features in individuals with neurofibromatosis type 1. One of these clinical biomarkers, macrocephaly, has been proposed ...
متن کاملGender as a disease modifier in neurofibromatosis type 1 optic pathway glioma.
In his very informative and thoughtful discussion of a patient with copper deficiency, Dr Samuels refers to the checklist concept in considering the differential diagnosis. He cites a Google search of myeloneuropathy and malnutrition as helping in suggesting the diagnosis. He further notes that searching on common nonspecific neurologic signs and symptoms generates exhaustive lists that would n...
متن کاملNon-optic glioma in adults and children with neurofibromatosis 1
BACKGROUND Non-optic gliomas occur in 5% of children with NF1, but little is known about these tumours in adults. We aimed to investigate progression, spontaneous regression and the natural history of non-optic gliomas in adults and compare these findings to the results found in children. RESULTS One thousand seven hundred twenty-two brain MRI scans of 562 unselected individuals with NF1 were...
متن کاملHigh-Dose Intravenous Vitamin C Treatment of a Child with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Case Report
BACKGROUND In neurofibromatosis type 1 (NF1) disease, the loss of the tumor suppressor function of the neurofibromin gene leads to proliferation of neural tumors. In children, the most frequently identified tumor is the optic pathway glioma. CASE REPORT We describe the case of a 5-year-old child who was diagnosed with NF1 and optic pathway tumor onset at the age of 14 months. Because of the tum...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2013
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/not120